7C7F
Crystal structures of AKR1C3 binary complex with NADP+
Summary for 7C7F
Entry DOI | 10.2210/pdb7c7f/pdb |
Descriptor | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | cancer, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 75953.89 |
Authors | Irie, K.,Toyooka, N.,Endo, S. (deposition date: 2020-05-25, release date: 2020-09-23, Last modification date: 2023-11-29) |
Primary citation | Endo, S.,Oguri, H.,Segawa, J.,Kawai, M.,Hu, D.,Xia, S.,Okada, T.,Irie, K.,Fujii, S.,Gouda, H.,Iguchi, K.,Matsukawa, T.,Fujimoto, N.,Nakayama, T.,Toyooka, N.,Matsunaga, T.,Ikari, A. Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer. J.Med.Chem., 63:10396-10411, 2020 Cited by PubMed: 32847363DOI: 10.1021/acs.jmedchem.0c00939 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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