7BUC

Crystal structure of EHMT2 SET domain in complex with compound 13

7BUC の概要

• エントリーDOI: 10.2210/pdb7buc/pdb
• 分子名称: Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• 機能のキーワード: protein-small molecule inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67208.86

構造登録者

Suzuki, M.,Mizuno, M.,Katayama, K. (登録日: 2020-04-06, 公開日: 2020-11-11, 最終更新日: 2023-11-29)

• 主引用文献: Katayama, K.,Ishii, K.,Tsuda, E.,Yotsumoto, K.,Hiramoto, K.,Suzuki, M.,Yasumatsu, I.,Igarashi, W.,Torihata, M.,Ishiyama, T.,Katagiri, T.; Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines.; Bioorg.Med.Chem.Lett., 30:127475-127475, 2020; PubMed: 32781218; DOI: 10.1016/j.bmcl.2020.127475

実験手法

X-RAY DIFFRACTION (2.6 Å)