7BTF

SARS-CoV-2 RNA-dependent RNA polymerase in complex with cofactors in reduced condition

7BTF の概要

• エントリーDOI: 10.2210/pdb7btf/pdb
• EMDBエントリー: 30178
• 分子名称: RNA-directed RNA polymerase, Non-structural protein 7, Non-structural protein 8, ... (4 entities in total)
• 機能のキーワード: covid-19, 2019-ncov, sars-cov-2, virus, rdrp, nsp12, nsp7, nsp8, rtc, cryo-em, viral protein, rna polymerase, drug target, antiviral, replication transcription complex
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 161348.18

構造登録者

Gao, Y.,Yan, L.,Huang, Y.,Liu, F.,Cao, L.,Wang, T.,Wang, Q.,Lou, Z.,Rao, Z. (登録日: 2020-04-01, 公開日: 2020-04-08, 最終更新日: 2024-03-27)

• 主引用文献: Gao, Y.,Yan, L.,Huang, Y.,Liu, F.,Zhao, Y.,Cao, L.,Wang, T.,Sun, Q.,Ming, Z.,Zhang, L.,Ge, J.,Zheng, L.,Zhang, Y.,Wang, H.,Zhu, Y.,Zhu, C.,Hu, T.,Hua, T.,Zhang, B.,Yang, X.,Li, J.,Yang, H.,Liu, Z.,Xu, W.,Guddat, L.W.,Wang, Q.,Lou, Z.,Rao, Z.; Structure of the RNA-dependent RNA polymerase from COVID-19 virus.; Science, 368:779-782, 2020; PubMed: 32277040; DOI: 10.1126/science.abb7498

実験手法

ELECTRON MICROSCOPY (2.95 Å)