7BSO

Crystal structure of the human NLRP9 pyrin domain

7BSO の概要

• エントリーDOI: 10.2210/pdb7bso/pdb
• 分子名称: NACHT, LRR and PYD domains-containing protein 9 (2 entities in total)
• 機能のキーワード: sensor component, nlrp9 inflammasome, apoptosis
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12807.89

構造登録者

Park, H.H.,Ha, H.J. (登録日: 2020-03-31, 公開日: 2021-02-10, 最終更新日: 2023-11-29)

主引用文献

Ha, H.J.,Park, H.H.
Crystal structure of the human NLRP9 pyrin domain reveals a bent N-terminal loop that may regulate inflammasome assembly.
Febs Lett., 594:2396-2405, 2020

PubMed Abstract: Members of the NLR family pyrin domain containing (NLRPs) are pattern recognition receptors that participate in innate immunity. They form inflammasomes, which are platforms for caspase-1 recruitment and activation. The NLRP pyrin domain (PYD) is critical for the assembly of inflammasomes due to its ability to mediate protein interactions. Despite intensive structural studies on inflammasomes with PYDs, the structure of the PYD of NLRP9-the least studied member of the family-remains unknown. Herein, we report the crystal structure of the human NLRP9 PYD at 2.1 Å resolution, which reveals a kinked N-terminal loop oriented toward the interior of the helical bundle. Based on our findings, we propose a regulatory role for the kinked N-terminal loop of NLRP9 PYD in inflammasome assembly.

PubMed: 32542766
DOI: 10.1002/1873-3468.13866

実験手法

X-RAY DIFFRACTION (2.08 Å)