7BOS

Human SIRT2 in complex with myristoyl thiourea inhibitor, No.13

7BOS の概要

• エントリーDOI: 10.2210/pdb7bos/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002361
• 分子名称: NAD-dependent protein deacetylase sirtuin-2, Myristoyl thiourea inhibitor, No.13, ZINC ION, ... (5 entities in total)
• 機能のキーワード: nad-dependent deacetylase, deacylase, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34089.78

構造登録者

Kudo, N.,Olsen, C.A.,Minoru, Y. (登録日: 2020-03-19, 公開日: 2021-03-24, 最終更新日: 2023-11-29)

• 主引用文献: Nielsen, A.L.,Rajabi, N.,Kudo, N.,Lundo, K.,Moreno-Yruela, C.,Baek, M.,Fontenas, M.,Lucidi, A.,Madsen, A.S.,Yoshida, M.,Olsen, C.A.; Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration.; Rsc Chem Biol, 2:612-626, 2021; PubMed: 34458803; DOI: 10.1039/d0cb00036a

実験手法

X-RAY DIFFRACTION (1.7 Å)