7BH5
XFEL structure of the ertapenem-derived CTX-M-15 acylenzyme after mixing for 2 sec using a piezoelectric injector (PolyPico)
Summary for 7BH5
Entry DOI | 10.2210/pdb7bh5/pdb |
Descriptor | Beta-lactamase, (2~{S},3~{R},4~{R})-3-[5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-4-methyl-5-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-2-carboxylic acid, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | serial crystallography, beta-lactamase, antibiotic, ertapenem, xfel, antimicrobial protein |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 28828.96 |
Authors | Hinchliffe, P.,Tooke, C.L.,Butryn, A.,Spencer, J. (deposition date: 2021-01-10, release date: 2021-07-21, Last modification date: 2024-01-31) |
Primary citation | Butryn, A.,Simon, P.S.,Aller, P.,Hinchliffe, P.,Massad, R.N.,Leen, G.,Tooke, C.L.,Bogacz, I.,Kim, I.S.,Bhowmick, A.,Brewster, A.S.,Devenish, N.E.,Brem, J.,Kamps, J.J.A.G.,Lang, P.A.,Rabe, P.,Axford, D.,Beale, J.H.,Davy, B.,Ebrahim, A.,Orlans, J.,Storm, S.L.S.,Zhou, T.,Owada, S.,Tanaka, R.,Tono, K.,Evans, G.,Owen, R.L.,Houle, F.A.,Sauter, N.K.,Schofield, C.J.,Spencer, J.,Yachandra, V.K.,Yano, J.,Kern, J.F.,Orville, A.M. An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Nat Commun, 12:4461-4461, 2021 Cited by PubMed: 34294694DOI: 10.1038/s41467-021-24757-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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