7BFX

deoxyxylose nucleic acid hairpin

7BFX の概要

• エントリーDOI: 10.2210/pdb7bfx/pdb
• 関連するPDBエントリー: 7BFS
• NMR情報: BMRB: 34588
• 分子名称: dXyNA (5'-D(*(XA)P*(XG)P*(XC)P*(XA)P*(XA)P*(XT)P*(XC)P*(XC)P*(XC)P*(XC)P*(XC)P*(XC)P*(XG)P*(XG)P*(XA)P*(XT)P*(XT)P*(XG)P*(XC)P*T)-3') (1 entity in total)
• 機能のキーワード: deoxyxylose nucleic acid, chimeric, dna
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6054.92

構造登録者

Mattelaer, C.-A.,Mohitosh, M.,Smets, L.,Maiti, M.,Schepers, G.,Mattelaer, H.-P.,Rosemeyer, H.,Herdewijn, P.,Lescrinier, E. (登録日: 2021-01-05, 公開日: 2021-01-27, 最終更新日: 2024-01-31)

主引用文献

Mattelaer, C.A.,Maiti, M.,Smets, L.,Maiti, M.,Schepers, G.,Mattelaer, H.P.,Rosemeyer, H.,Herdewijn, P.,Lescrinier, E.
Stable Hairpin Structures Formed by Xylose-Based Nucleic Acids.
Chembiochem, 22:1638-1645, 2021

PubMed Abstract: Xenobiology explores synthetic nucleic acid polymers as alternative carriers of genetic information to expand the central dogma. The xylo- and deoxyxylo-nucleic acids (XyNA and dXyNA), containing 3' epimers of riboses and deoxyriboses, are considered to be potential candidates for an orthogonal system. In this study, thermal and spectroscopic analyses show that XyNA and dXyNA form stable hairpins. The dXyNA hairpin structure determined by NMR spectroscopy contains a flexible loop that locks the stem into a stable ladder-like duplex with marginal right-handed helicity. The reduced flexibility of the dXyNA duplex observed in the stem of the hairpin demonstrates that folding of dXyNA yields more stable structures described so far.

PubMed: 33427360
DOI: 10.1002/cbic.202000803

実験手法

SOLUTION NMR