7BE8
Escherichia coli YtfE (Mn)
Summary for 7BE8
| Entry DOI | 10.2210/pdb7be8/pdb |
| Descriptor | Iron-sulfur cluster repair protein YtfE, MANGANESE (II) ION, OXYGEN ATOM, ... (6 entities in total) |
| Functional Keywords | di-iron, metal binding protein |
| Biological source | Escherichia coli (strain K12) |
| Total number of polymer chains | 2 |
| Total formula weight | 50515.28 |
| Authors | Silva, L.S.O.,Matias, P.M.,Romao, C.V.,Saraiva, L.M. (deposition date: 2020-12-22, release date: 2022-01-12, Last modification date: 2024-10-23) |
| Primary citation | Silva, L.S.O.,Matias, P.M.,Romao, C.V.,Saraiva, L.M. Repair of Iron Center Proteins-A Different Class of Hemerythrin-like Proteins. Molecules, 27:-, 2022 Cited by PubMed Abstract: Repair of Iron Center proteins (RIC) form a family of di-iron proteins that are widely spread in the microbial world. RICs contain a binuclear nonheme iron site in a four-helix bundle fold, two basic features of hemerythrin-like proteins. In this work, we review the data on microbial RICs including how their genes are regulated and contribute to the survival of pathogenic bacteria. We gathered the currently available biochemical, spectroscopic and structural data on RICs with a particular focus on RIC (also known as YtfE), which remains the best-studied protein with extensive biochemical characterization. Additionally, we present novel structural data for YtfE harboring a di-manganese site and the protein's affinity for this metal. The networking of protein interactions involving YtfE is also described and integrated into the proposed physiological role as an iron donor for reassembling of stress-damaged iron-sulfur centers. PubMed: 35807291DOI: 10.3390/molecules27134051 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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