7BE8

Escherichia coli YtfE (Mn)

7BE8 の概要

• エントリーDOI: 10.2210/pdb7be8/pdb
• 分子名称: Iron-sulfur cluster repair protein YtfE, MANGANESE (II) ION, OXYGEN ATOM, ... (6 entities in total)
• 機能のキーワード: di-iron, metal binding protein
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50515.28

構造登録者

Silva, L.S.O.,Matias, P.M.,Romao, C.V.,Saraiva, L.M. (登録日: 2020-12-22, 公開日: 2022-01-12, 最終更新日: 2024-10-23)

主引用文献

Silva, L.S.O.,Matias, P.M.,Romao, C.V.,Saraiva, L.M.
Repair of Iron Center Proteins-A Different Class of Hemerythrin-like Proteins.
Molecules, 27:-, 2022

PubMed Abstract: Repair of Iron Center proteins (RIC) form a family of di-iron proteins that are widely spread in the microbial world. RICs contain a binuclear nonheme iron site in a four-helix bundle fold, two basic features of hemerythrin-like proteins. In this work, we review the data on microbial RICs including how their genes are regulated and contribute to the survival of pathogenic bacteria. We gathered the currently available biochemical, spectroscopic and structural data on RICs with a particular focus on RIC (also known as YtfE), which remains the best-studied protein with extensive biochemical characterization. Additionally, we present novel structural data for YtfE harboring a di-manganese site and the protein's affinity for this metal. The networking of protein interactions involving YtfE is also described and integrated into the proposed physiological role as an iron donor for reassembling of stress-damaged iron-sulfur centers.

PubMed: 35807291
DOI: 10.3390/molecules27134051

実験手法

X-RAY DIFFRACTION (2.02 Å)