7BE7
Crystal structure of MG-132 covalently bound to the main protease (3CLpro/Mpro) of SARS-CoV-2.
Summary for 7BE7
Entry DOI | 10.2210/pdb7be7/pdb |
Related PRD ID | PRD_001210 |
Descriptor | 3C-like proteinase, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | sars-cov-2, mpro, 3clpro, exscalate4cov, drug discovery, elettra, viral protein, mg-132 |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 2 |
Total formula weight | 69577.82 |
Authors | Costanzi, E.,Demitri, N.,Giabbai, B.,Storici, P. (deposition date: 2020-12-22, release date: 2021-03-03, Last modification date: 2024-01-31) |
Primary citation | Costanzi, E.,Kuzikov, M.,Esposito, F.,Albani, S.,Demitri, N.,Giabbai, B.,Camasta, M.,Tramontano, E.,Rossetti, G.,Zaliani, A.,Storici, P. Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L. Int J Mol Sci, 22:-, 2021 Cited by PubMed: 34769210DOI: 10.3390/ijms222111779 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
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