7BDS

Structure of CTX-M-15 crystallised in the presence of tazobactam

7BDS の概要

• エントリーDOI: 10.2210/pdb7bds/pdb
• 分子名称: Beta-lactamase, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: beta-lactamase, inhibitor, antibiotic resistance, cross-link, antimicrobial protein
• 由来する生物種: Klebsiella pneumoniae IS53
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28600.63

構造登録者

Tooke, C.L.,Hinchliffe, P.,Spencer, J. (登録日: 2020-12-22, 公開日: 2022-01-12, 最終更新日: 2024-01-31)

• 主引用文献: Hinchliffe, P.,Tooke, C.L.,Bethel, C.R.,Wang, B.,Arthur, C.,Heesom, K.J.,Shapiro, S.,Schlatzer, D.M.,Papp-Wallace, K.M.,Bonomo, R.A.,Spencer, J.; Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition.; Mbio, 13:e0179321-e0179321, 2022; PubMed: 35612361; DOI: 10.1128/mbio.01793-21

実験手法

X-RAY DIFFRACTION (0.91 Å)