7BDO

MAPK14 bound with SR302

7BDO の概要

• エントリーDOI: 10.2210/pdb7bdo/pdb
• 分子名称: Mitogen-activated protein kinase 14, ~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{S})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: p38a, inhibitor, mapk14, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42017.99

構造登録者

Schroeder, M.,Roehm, S.,Joerger, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-12-22, 公開日: 2021-03-03, 最終更新日: 2024-01-31)

• 主引用文献: Rohm, S.,Berger, B.T.,Schroder, M.,Chatterjee, D.,Mathea, S.,Joerger, A.C.,Pinkas, D.M.,Bufton, J.C.,Tjaden, A.,Kovooru, L.,Kudolo, M.,Pohl, C.,Bullock, A.N.,Muller, S.,Laufer, S.,Knapp, S.; Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.; J.Med.Chem., 64:13451-13474, 2021; PubMed: 34506142; DOI: 10.1021/acs.jmedchem.1c00868

実験手法

X-RAY DIFFRACTION (2.7 Å)