7B9L

MEK1 in complex with compound 23

7B9L の概要

• エントリーDOI: 10.2210/pdb7b9l/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ~{N}-(4-methoxyphenyl)-2-[(2~{S})-3-oxidanylidenethiomorpholin-2-yl]ethanamide, ... (7 entities in total)
• 機能のキーワード: kinase, allosteric, fragments, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74925.85

構造登録者

Kack, H.,Oster, L. (登録日: 2020-12-14, 公開日: 2021-03-03, 最終更新日: 2024-01-31)

• 主引用文献: Di Fruscia, P.,Edfeldt, F.,Shamovsky, I.,Collie, G.W.,Aagaard, A.,Barlind, L.,Borjesson, U.,Hansson, E.L.,Lewis, R.J.,Nilsson, M.K.,Oster, L.,Pemberton, J.,Ripa, L.,Storer, R.I.,Kack, H.; Fragment-Based Discovery of Novel Allosteric MEK1 Binders.; Acs Med.Chem.Lett., 12:302-308, 2021; PubMed: 33603979; DOI: 10.1021/acsmedchemlett.0c00563

実験手法

X-RAY DIFFRACTION (1.7 Å)