7B8H

Monoclinic structure of human protein kinase CK2 catalytic subunit in complex with a heparin oligo saccharide

7B8H の概要

• エントリーDOI: 10.2210/pdb7b8h/pdb
• 分子名称: Casein kinase II subunit alpha, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: protein kinase ck2, casein kinase 2, catalytic subunit ck2alpha, heparin, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41711.09

構造登録者

Niefind, K.,Schnitzler, A. (登録日: 2020-12-12, 公開日: 2021-02-03, 最終更新日: 2024-05-15)

• 主引用文献: Schnitzler, A.,Niefind, K.; Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin.; Eur.J.Med.Chem., 214:113223-113223, 2021; PubMed: 33571828; DOI: 10.1016/j.ejmech.2021.113223

実験手法

X-RAY DIFFRACTION (1.34 Å)