7B88

Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with S99 inhibitor

Summary for 7B88

• Entry DOI: 10.2210/pdb7b88/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 3-[5-[3,5-bis(chloranyl)phenyl]-4-phenyl-1,3-oxazol-2-yl]propanoic acid, ... (4 entities in total)
• Functional Keywords: rxr alpha, rxra, inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 27923.23

Authors

Chaikuad, A.,Schierle, S.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-12-12, release date: 2021-01-13, Last modification date: 2024-01-31)

• Primary citation: Schierle, S.,Chaikuad, A.,Lillich, F.F.,Ni, X.,Woltersdorf, S.,Schallmayer, E.,Renelt, B.,Ronchetti, R.,Knapp, S.,Proschak, E.,Merk, D.; Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.; J.Med.Chem., 64:5123-5136, 2021; PubMed: 33793232; DOI: 10.1021/acs.jmedchem.1c00235

Experimental method

X-RAY DIFFRACTION (2.38 Å)