7B7V
Structure of NUDT15 in complex with Acyclovir monophosphate
Summary for 7B7V
Entry DOI | 10.2210/pdb7b7v/pdb |
Descriptor | Probable 8-oxo-dGTP diphosphatase NUDT15, 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl dihydrogen phosphate, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | nucleoside triphosphate pyrophosphohydrolase, complex, antiviral hydrolase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 38048.50 |
Authors | Rehling, D.,Stenmark, P. (deposition date: 2020-12-11, release date: 2021-05-19, Last modification date: 2024-01-31) |
Primary citation | Nishii, R.,Mizuno, T.,Rehling, D.,Smith, C.,Clark, B.L.,Zhao, X.,Brown, S.A.,Smart, B.,Moriyama, T.,Yamada, Y.,Ichinohe, T.,Onizuka, M.,Atsuta, Y.,Yang, L.,Yang, W.,Thomas, P.G.,Stenmark, P.,Kato, M.,Yang, J.J. NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir. Nat Commun, 12:4181-4181, 2021 Cited by PubMed: 34234136DOI: 10.1038/s41467-021-24509-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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