7B7V

Structure of NUDT15 in complex with Acyclovir monophosphate

7B7V の概要

• エントリーDOI: 10.2210/pdb7b7v/pdb
• 分子名称: Probable 8-oxo-dGTP diphosphatase NUDT15, 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl dihydrogen phosphate, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: nucleoside triphosphate pyrophosphohydrolase, complex, antiviral hydrolase, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38048.50

構造登録者

Rehling, D.,Stenmark, P. (登録日: 2020-12-11, 公開日: 2021-05-19, 最終更新日: 2024-01-31)

• 主引用文献: Nishii, R.,Mizuno, T.,Rehling, D.,Smith, C.,Clark, B.L.,Zhao, X.,Brown, S.A.,Smart, B.,Moriyama, T.,Yamada, Y.,Ichinohe, T.,Onizuka, M.,Atsuta, Y.,Yang, L.,Yang, W.,Thomas, P.G.,Stenmark, P.,Kato, M.,Yang, J.J.; NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir.; Nat Commun, 12:4181-4181, 2021; PubMed: 34234136; DOI: 10.1038/s41467-021-24509-7

実験手法

X-RAY DIFFRACTION (1.6 Å)