7B6W

Crystal structure of the human alpha1B adrenergic receptor in complex with inverse agonist (+)-cyclazosin

This is a non-PDB format compatible entry.

Summary for 7B6W

• Entry DOI: 10.2210/pdb7b6w/pdb
• Descriptor: Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor, [(4~{a}~{R},8~{a}~{S})-4-(4-azanyl-6,7-dimethoxy-quinazolin-2-yl)-2,3,4~{a},5,6,7,8,8~{a}-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone (2 entities in total)
• Functional Keywords: gpcr-ligand complex, alpha1b adrenergic receptor, cyclazosin, inverse agonist, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 50880.41

Authors

Deluigi, M.,Morstein, L.,Hilge, M.,Schuster, M.,Merklinger, L.,Klipp, A.,Scott, D.J.,Plueckthun, A. (deposition date: 2020-12-08, release date: 2022-01-12, Last modification date: 2024-05-01)

• Primary citation: Deluigi, M.,Morstein, L.,Schuster, M.,Klenk, C.,Merklinger, L.,Cridge, R.R.,de Zhang, L.A.,Klipp, A.,Vacca, S.,Vaid, T.M.,Mittl, P.R.E.,Egloff, P.,Eberle, S.A.,Zerbe, O.,Chalmers, D.K.,Scott, D.J.,Pluckthun, A.; Crystal structure of the alpha 1B -adrenergic receptor reveals molecular determinants of selective ligand recognition.; Nat Commun, 13:382-382, 2022; PubMed: 35046410; DOI: 10.1038/s41467-021-27911-3

Experimental method

X-RAY DIFFRACTION (2.873 Å)