7B67

Structure of NUDT15 V18_V19insGV Mutant in complex with TH7755

7B67 の概要

• エントリーDOI: 10.2210/pdb7b67/pdb
• 分子名称: Nucleotide triphosphate diphosphatase NUDT15, (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, nucleoside triphosphate pyrophosphohydrolase, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38610.65

構造登録者

Rehling, D.,Stenmark, P. (登録日: 2020-12-07, 公開日: 2021-03-24, 最終更新日: 2024-01-31)

• 主引用文献: Rehling, D.,Zhang, S.M.,Jemth, A.S.,Koolmeister, T.,Throup, A.,Wallner, O.,Scaletti, E.,Moriyama, T.,Nishii, R.,Davies, J.,Desroses, M.,Rudd, S.G.,Scobie, M.,Homan, E.,Berglund, U.W.,Yang, J.J.,Helleday, T.,Stenmark, P.; Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.; J.Biol.Chem., 296:100568-100568, 2021; PubMed: 33753169; DOI: 10.1016/j.jbc.2021.100568

実験手法

X-RAY DIFFRACTION (1.45 Å)