7B41

Crystal structure of c-MET bound by compound 7

7B41 の概要

• エントリーDOI: 10.2210/pdb7b41/pdb
• 分子名称: Hepatocyte growth factor receptor, 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine (3 entities in total)
• 機能のキーワード: c-met, kinase, folded p-loop, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34161.65

構造登録者

Collie, G.W. (登録日: 2020-12-02, 公開日: 2020-12-09, 最終更新日: 2024-05-01)

• 主引用文献: Collie, G.W.,Michaelides, I.N.,Embrey, K.,Stubbs, C.J.,Borjesson, U.,Dale, I.L.,Snijder, A.,Barlind, L.,Song, K.,Khurana, P.,Phillips, C.,Storer, R.I.; Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.; Acs Med.Chem.Lett., 12:162-167, 2021; PubMed: 33488978; DOI: 10.1021/acsmedchemlett.0c00392

実験手法

X-RAY DIFFRACTION (1.97 Å)