7B39

Allene-Based Design of a Noncalcemic Vitamin D Receptor Agonist

7B39 の概要

• エントリーDOI: 10.2210/pdb7b39/pdb
• 分子名称: Vitamin D3 receptor A, Nuclear receptor coactivator 1, (1R,3S,Z)-5-(2-((3aS,7aS,E)-1-(6-hydroxy-6-methylhept-1-en-1-ylidene)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol, ... (5 entities in total)
• 機能のキーワード: vitamin d receptor, gene regulation
• 由来する生物種: Danio rerio (Zebrafish); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36308.39

構造登録者

Rochel, N. (登録日: 2020-11-29, 公開日: 2021-09-01, 最終更新日: 2024-01-31)

• 主引用文献: Fraga, R.,Len, K.,Lutzing, R.,Laverny, G.,Loureiro, J.,Maestro, M.A.,Rochel, N.,Rodriguez-Borges, E.,Mourino, A.; Design, Synthesis, Evaluation and Structure of Allenic 1 alpha ,25-Dihydroxyvitamin D 3 Analogs with Locked Mobility at C-17.; Chemistry, 27:13384-13389, 2021; PubMed: 34224173; DOI: 10.1002/chem.202101578

実験手法

X-RAY DIFFRACTION (2.13 Å)