7B33
MST3 in complex with MRIA11
Summary for 7B33
Entry DOI | 10.2210/pdb7b33/pdb |
Descriptor | Serine/threonine-protein kinase 24, 1,2-ETHANEDIOL, 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[4-[6-[bis(fluoranyl)methyl]pyridin-2-yl]-2-chloranyl-phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, ... (4 entities in total) |
Functional Keywords | kinase inhibitors, structure-based drug design, sik2 inhibitor, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35336.86 |
Authors | Tesch, R.,Rak, M.,Joerger, A.C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-28, release date: 2020-12-16, Last modification date: 2024-01-31) |
Primary citation | Tesch, R.,Rak, M.,Raab, M.,Berger, L.M.,Kronenberger, T.,Joerger, A.C.,Berger, B.T.,Abdi, I.,Hanke, T.,Poso, A.,Strebhardt, K.,Sanhaji, M.,Knapp, S. Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. J.Med.Chem., 64:8142-8160, 2021 Cited by PubMed: 34086472DOI: 10.1021/acs.jmedchem.0c02144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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