7B31

MST3 in complex with compound MRIA9

Summary for 7B31

Entry DOI	10.2210/pdb7b31/pdb
Descriptor	Serine/threonine-protein kinase 24, 1-[(5-azanyl-1,3-dioxan-2-yl)methyl]-3-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-7-(methylamino)-1,6-naphthyridin-2-one (3 entities in total)
Functional Keywords	kinase inhibitors, structure-based drug design, sik2 inhibitor, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35055.58
Authors	Tesch, R.,Rak, M.,Joerger, A.C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-28, release date: 2020-12-16, Last modification date: 2024-01-31)
Primary citation	Tesch, R.,Rak, M.,Raab, M.,Berger, L.M.,Kronenberger, T.,Joerger, A.C.,Berger, B.T.,Abdi, I.,Hanke, T.,Poso, A.,Strebhardt, K.,Sanhaji, M.,Knapp, S. Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. J.Med.Chem., 64:8142-8160, 2021 Cited by PubMed: 34086472 DOI: 10.1021/acs.jmedchem.0c02144 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation