7B31

MST3 in complex with compound MRIA9

7B31 の概要

• エントリーDOI: 10.2210/pdb7b31/pdb
• 分子名称: Serine/threonine-protein kinase 24, 1-[(5-azanyl-1,3-dioxan-2-yl)methyl]-3-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-7-(methylamino)-1,6-naphthyridin-2-one (3 entities in total)
• 機能のキーワード: kinase inhibitors, structure-based drug design, sik2 inhibitor, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35055.58

構造登録者

Tesch, R.,Rak, M.,Joerger, A.C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-11-28, 公開日: 2020-12-16, 最終更新日: 2024-01-31)

• 主引用文献: Tesch, R.,Rak, M.,Raab, M.,Berger, L.M.,Kronenberger, T.,Joerger, A.C.,Berger, B.T.,Abdi, I.,Hanke, T.,Poso, A.,Strebhardt, K.,Sanhaji, M.,Knapp, S.; Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.; J.Med.Chem., 64:8142-8160, 2021; PubMed: 34086472; DOI: 10.1021/acs.jmedchem.0c02144

実験手法

X-RAY DIFFRACTION (1.8 Å)