7B0V

Crystal Structure of human monoamine oxidase B in complex with (E)-3-phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one

Summary for 7B0V

• Entry DOI: 10.2210/pdb7b0v/pdb
• Descriptor: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, (E)-3-phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one, ... (6 entities in total)
• Functional Keywords: monoamine oxidase, drug target, neurodegeneration, flavin, chalcone, mitochondrial membrane, flavoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 120656.36

Authors

Iacovino, L.G.,Binda, C. (deposition date: 2020-11-23, release date: 2021-11-03, Last modification date: 2024-01-31)

• Primary citation: Iacovino, L.G.,Pinzi, L.,Facchetti, G.,Bortolini, B.,Christodoulou, M.S.,Binda, C.,Rastelli, G.,Rimoldi, I.,Passarella, D.,Di Paolo, M.L.,Dalla Via, L.; Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B.; Acs Med.Chem.Lett., 12:1151-1158, 2021; PubMed: 34262643; DOI: 10.1021/acsmedchemlett.1c00238

Experimental method

X-RAY DIFFRACTION (2.3 Å)