7AYI

Crystal structure of Aurora A in complex with 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-one derivative (compound 2a)

Summary for 7AYI

• Entry DOI: 10.2210/pdb7ayi/pdb
• Descriptor: Aurora kinase A, 7-(2-phenylazanylpyrimidin-4-yl)-1,3,4,5-tetrahydro-1-benzazepin-2-one (2 entities in total)
• Functional Keywords: kinase, kinase inhibitor, aurora kinase, stk6, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33279.16

Authors

Chaikuad, A.,Karatas, M.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-12, release date: 2021-01-13, Last modification date: 2024-01-31)

• Primary citation: Karatas, M.,Chaikuad, A.,Berger, B.,Kubbutat, M.H.G.,Totzke, F.,Knapp, S.,Kunick, C.; 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors.; Molecules, 26:-, 2021; PubMed: 33799460; DOI: 10.3390/molecules26061611

Experimental method

X-RAY DIFFRACTION (2.86 Å)