7AYI

Crystal structure of Aurora A in complex with 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-one derivative (compound 2a)

7AYI の概要

• エントリーDOI: 10.2210/pdb7ayi/pdb
• 分子名称: Aurora kinase A, 7-(2-phenylazanylpyrimidin-4-yl)-1,3,4,5-tetrahydro-1-benzazepin-2-one (2 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, aurora kinase, stk6, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33279.16

構造登録者

Chaikuad, A.,Karatas, M.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-11-12, 公開日: 2021-01-13, 最終更新日: 2024-01-31)

• 主引用文献: Karatas, M.,Chaikuad, A.,Berger, B.,Kubbutat, M.H.G.,Totzke, F.,Knapp, S.,Kunick, C.; 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors.; Molecules, 26:-, 2021; PubMed: 33799460; DOI: 10.3390/molecules26061611

実験手法

X-RAY DIFFRACTION (2.86 Å)