7AWM

Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP, three sodium ions and the allosteric inhibitor UCPH101

7AWM の概要

• エントリーDOI: 10.2210/pdb7awm/pdb
• 分子名称: Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, SODIUM ION, ASPARTIC ACID, ... (5 entities in total)
• 機能のキーワード: excitatory amino acid transporter 1, human glutamate transporter, slc1a3, allosteric inhibitor ucph101, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57274.25

構造登録者

Canul-Tec, J.C.,Legrand, P.,Reyes, N. (登録日: 2020-11-08, 公開日: 2021-10-13, 最終更新日: 2024-01-31)

• 主引用文献: Canul-Tec, J.C.,Kumar, A.,Dhenin, J.,Assal, R.,Legrand, P.,Rey, M.,Chamot-Rooke, J.,Reyes, N.; The ion-coupling mechanism of human excitatory amino acid transporters.; Embo J., 41:e108341-e108341, 2022; PubMed: 34747040; DOI: 10.15252/embj.2021108341

実験手法

X-RAY DIFFRACTION (3.25 Å)