7AWG

Crystal structure of human butyrylcholinesterase in complex with (2-((1-(benzenesulfonyl)-1H-indol-4-yl)oxy)ethyl)(benzyl)amine

7AWG の概要

• エントリーDOI: 10.2210/pdb7awg/pdb
• 分子名称: Cholinesterase, GLYCEROL, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: butyrylcholinesterase, inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63977.78

構造登録者

Brazzolotto, X.,Wichur, T.,Wieckowska, A. (登録日: 2020-11-08, 公開日: 2021-09-29, 最終更新日: 2024-01-31)

• 主引用文献: Wichur, T.,Godyn, J.,Goral, I.,Latacz, G.,Bucki, A.,Siwek, A.,Gluch-Lutwin, M.,Mordyl, B.,Sniecikowska, J.,Walczak, M.,Knez, D.,Jukic, M.,Salat, K.,Gobec, S.,Kolaczkowski, M.,Malawska, B.,Brazzolotto, X.,Wieckowska, A.; Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT 6 R antagonists with beta-amyloid anti-aggregation properties.; Eur.J.Med.Chem., 225:113792-113792, 2021; PubMed: 34530376; DOI: 10.1016/j.ejmech.2021.113792

実験手法

X-RAY DIFFRACTION (2 Å)