7AVJ

Streptococcal High Identity Repeats in Tandem (SHIRT) domain 2 from cell surface protein SGO_0707

7AVJ の概要

• エントリーDOI: 10.2210/pdb7avj/pdb
• 分子名称: LPXTG cell wall surface protein (2 entities in total)
• 機能のキーワード: bacterial surface, adhesin, tandem repeat, sgo0707, cell adhesion
• 由来する生物種: Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9627.49

構造登録者

Whelan, F.,Jenkins, H.T.,Potts, J.R. (登録日: 2020-11-05, 公開日: 2021-06-09, 最終更新日: 2024-05-15)

主引用文献

Whelan, F.,Lafita, A.,Gilburt, J.,Degut, C.,Griffiths, S.C.,Jenkins, H.T.,St John, A.N.,Paci, E.,Moir, J.W.B.,Plevin, M.J.,Baumann, C.G.,Bateman, A.,Potts, J.R.
Periscope Proteins are variable-length regulators of bacterial cell surface interactions.
Proc.Natl.Acad.Sci.USA, 118:-, 2021

PubMed Abstract: Changes at the cell surface enable bacteria to survive in dynamic environments, such as diverse niches of the human host. Here, we reveal "Periscope Proteins" as a widespread mechanism of bacterial surface alteration mediated through protein length variation. Tandem arrays of highly similar folded domains can form an elongated rod-like structure; thus, variation in the number of domains determines how far an N-terminal host ligand binding domain projects from the cell surface. Supported by newly available long-read genome sequencing data, we propose that this class could contain over 50 distinct proteins, including those implicated in host colonization and biofilm formation by human pathogens. In large multidomain proteins, sequence divergence between adjacent domains appears to reduce interdomain misfolding. Periscope Proteins break this "rule," suggesting that their length variability plays an important role in regulating bacterial interactions with host surfaces, other bacteria, and the immune system.

PubMed: 34074781
DOI: 10.1073/pnas.2101349118

実験手法

X-RAY DIFFRACTION (0.95 Å)