7AT5
Structure of protein kinase ck2 catalytic subunit (csnk2a1 gene product) in complex with the bivalent inhibitor KN2
Summary for 7AT5
Entry DOI | 10.2210/pdb7at5/pdb |
Descriptor | Casein kinase II subunit alpha, SULFATE ION, ~{N}'-[2-(3,4-dichlorophenyl)ethyl]-~{N}-[4-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]butyl]butanediamide, ... (6 entities in total) |
Functional Keywords | protein kinase ck2, casein kinase 2, bivalent inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 85875.38 |
Authors | Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Goetz, C.,Jose, J.,Niefind, K. (deposition date: 2020-10-29, release date: 2021-08-04, Last modification date: 2024-01-31) |
Primary citation | Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Gotz, C.,Jose, J.,Niefind, K. Molecular Plasticity of Crystalline CK2 alpha ' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. J.Med.Chem., 65:1302-1312, 2022 Cited by PubMed: 34323071DOI: 10.1021/acs.jmedchem.1c00063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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