7AT5

Structure of protein kinase ck2 catalytic subunit (csnk2a1 gene product) in complex with the bivalent inhibitor KN2

7AT5 の概要

• エントリーDOI: 10.2210/pdb7at5/pdb
• 分子名称: Casein kinase II subunit alpha, SULFATE ION, ~{N}'-[2-(3,4-dichlorophenyl)ethyl]-~{N}-[4-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]butyl]butanediamide, ... (6 entities in total)
• 機能のキーワード: protein kinase ck2, casein kinase 2, bivalent inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85875.38

構造登録者

Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Goetz, C.,Jose, J.,Niefind, K. (登録日: 2020-10-29, 公開日: 2021-08-04, 最終更新日: 2024-01-31)

• 主引用文献: Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Gotz, C.,Jose, J.,Niefind, K.; Molecular Plasticity of Crystalline CK2 alpha ' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity.; J.Med.Chem., 65:1302-1312, 2022; PubMed: 34323071; DOI: 10.1021/acs.jmedchem.1c00063

実験手法

X-RAY DIFFRACTION (1.77 Å)