7ASD

Structure of native royal jelly filaments

これはPDB形式変換不可エントリーです。

7ASD の概要

• エントリーDOI: 10.2210/pdb7asd/pdb
• 関連するPDBエントリー: 5YYL
• EMDBエントリー: 11892
• 分子名称: Major royal jelly protein 1, Apisimin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: protein filament, lipoprotein, glycosylation, royal jelly, major royal jelly protein, honeybee, protein fibril
• 由来する生物種: Apis mellifera (Honeybee); 詳細
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 472078.12

構造登録者

Mattei, S.,Ban, A.,Picenoni, A.,Leibundgut, M.,Glockshuber, R.,Boehringer, D. (登録日: 2020-10-27, 公開日: 2020-12-30, 最終更新日: 2024-11-13)

主引用文献

Mattei, S.,Ban, A.,Picenoni, A.,Leibundgut, M.,Glockshuber, R.,Boehringer, D.
Structure of native glycolipoprotein filaments in honeybee royal jelly.
Nat Commun, 11:6267-6267, 2020

PubMed Abstract: Royal jelly (RJ) is produced by honeybees (Apis mellifera) as nutrition during larval development. The high viscosity of RJ originates from high concentrations of long lipoprotein filaments that include the glycosylated major royal jelly protein 1 (MRJP1), the small protein apisimin and insect lipids. Using cryo-electron microscopy we reveal the architecture and the composition of RJ filaments, in which the MRJP1 forms the outer shell of the assembly, surrounding stacked apisimin tetramers harbouring tightly packed lipids in the centre. The structural data rationalize the pH-dependent disassembly of RJ filaments in the gut of the larvae.

PubMed: 33293513
DOI: 10.1038/s41467-020-20135-x

実験手法

ELECTRON MICROSCOPY (3.5 Å)