7ARS

The de novo designed hybrid alpha/beta-miniprotein (with Se-Methionine)

7ARS の概要

• エントリーDOI: 10.2210/pdb7ars/pdb
• 関連するPDBエントリー: 7ARR
• 分子名称: alpha/beta-peptide, trifluoroacetic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: alpha/beta-peptide, foldamer, de novo protein
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 8431.43

構造登録者

Bejger, M.,Fortuna, P.,Drewniak-Switalska, M.,Rypniewski, W.,Berlicki, L. (登録日: 2020-10-26, 公開日: 2021-07-14, 最終更新日: 2024-05-01)

主引用文献

Bejger, M.,Fortuna, P.,Drewniak-Switalska, M.,Plewka, J.,Rypniewski, W.,Berlicki, L.
A computationally designed beta-amino acid-containing miniprotein.
Chem.Commun.(Camb.), 57:6015-6018, 2021

PubMed Abstract: A new miniprotein built from three helices, including one structure based on the ααβαααβ sequence pattern was developed. Its crystal structure revealed a compact conformation with a well-packed hydrophobic core of unprecedented structure. The miniprotein formed dimers that were stabilized by the interaction of their hydrophobic surfaces.

PubMed: 34032224
DOI: 10.1039/d1cc02192c

実験手法

X-RAY DIFFRACTION (1.15 Å)