7APG

Crystal structure of JAK3 in complex with FM587 (compound 9a)

7APG の概要

• エントリーDOI: 10.2210/pdb7apg/pdb
• 分子名称: Tyrosine-protein kinase JAK3, ~{N}-[3-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide, 1-phenylurea, ... (5 entities in total)
• 機能のキーワード: kinase, jak3, inhibitor, covalent inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 136392.19

構造登録者

Chaikuad, A.,Forster, M.,Gehringer, M.,Laufer, S.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-10-16, 公開日: 2020-12-02, 最終更新日: 2024-01-31)

• 主引用文献: Forster, M.,Liang, X.J.,Schroder, M.,Gerstenecker, S.,Chaikuad, A.,Knapp, S.,Laufer, S.,Gehringer, M.; Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK.; Int J Mol Sci, 21:-, 2020; PubMed: 33291717; DOI: 10.3390/ijms21239269

実験手法

X-RAY DIFFRACTION (2.4 Å)