7AMZ

Crystal structure of human Butyrylcholinesterase in complex with N-((2S,3R)-4-((2,2-dimethylpropyl)amino)-3-hydroxy-1-phenylbutan-2-yl)-2,2-diphenylacetamide

Summary for 7AMZ

• Entry DOI: 10.2210/pdb7amz/pdb
• Descriptor: Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: butyrylcholinesterase, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 63653.43

Authors

Brazzolotto, X.,Pasieka, A.,Panek, D.,Wieckowska, A. (deposition date: 2020-10-10, release date: 2021-05-26, Last modification date: 2024-01-31)

• Primary citation: Pasieka, A.,Panek, D.,Jonczyk, J.,Godyn, J.,Szalaj, N.,Latacz, G.,Tabor, J.,Mezeiova, E.,Chantegreil, F.,Dias, J.,Knez, D.,Lu, J.,Pi, R.,Korabecny, J.,Brazzolotto, X.,Gobec, S.,Hofner, G.,Wanner, K.,Wieckowska, A.,Malawska, B.; Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters.; Eur.J.Med.Chem., 218:113397-113397, 2021; PubMed: 33838585; DOI: 10.1016/j.ejmech.2021.113397

Experimental method

X-RAY DIFFRACTION (2.25 Å)