7AMZ
Crystal structure of human Butyrylcholinesterase in complex with N-((2S,3R)-4-((2,2-dimethylpropyl)amino)-3-hydroxy-1-phenylbutan-2-yl)-2,2-diphenylacetamide
Summary for 7AMZ
Entry DOI | 10.2210/pdb7amz/pdb |
Descriptor | Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | butyrylcholinesterase, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 63653.43 |
Authors | Brazzolotto, X.,Pasieka, A.,Panek, D.,Wieckowska, A. (deposition date: 2020-10-10, release date: 2021-05-26, Last modification date: 2024-01-31) |
Primary citation | Pasieka, A.,Panek, D.,Jonczyk, J.,Godyn, J.,Szalaj, N.,Latacz, G.,Tabor, J.,Mezeiova, E.,Chantegreil, F.,Dias, J.,Knez, D.,Lu, J.,Pi, R.,Korabecny, J.,Brazzolotto, X.,Gobec, S.,Hofner, G.,Wanner, K.,Wieckowska, A.,Malawska, B. Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters. Eur.J.Med.Chem., 218:113397-113397, 2021 Cited by PubMed: 33838585DOI: 10.1016/j.ejmech.2021.113397 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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