7A9S

Racemic compound of RNA duplexes.

7A9S の概要

• エントリーDOI: 10.2210/pdb7a9s/pdb
• 関連するPDBエントリー: 6ZPF 6ZQ9 6ZR1 6ZRL 6ZRS 6ZW3 6ZWU 6ZX5 6ZX8
• 分子名称: RNA (5'-R(*CP*UP*GP*GP*GP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*CP*CP*UP*GP*G)-3'), RNA (5'-R(*(0C)P*(0U)P*(0G)P*(0G)P*(0G)P*(0C)P*(0G)P*(0G))-3'), ... (6 entities in total)
• 機能のキーワード: racemic compound, rna
• 由来する生物種: Thermus thermophilus; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 10688.17

構造登録者

Rypniewski, W. (登録日: 2020-09-02, 公開日: 2021-05-26, 最終更新日: 2024-01-31)

主引用文献

Kiliszek, A.,Blaszczyk, L.,Bejger, M.,Rypniewski, W.
Broken symmetry between RNA enantiomers in a crystal lattice.
Nucleic Acids Res., 49:12535-12539, 2021

PubMed Abstract: Explaining the origin of the homochirality of biological molecules requires a mechanism of disrupting the natural equilibrium between enantiomers and amplifying the initial imbalance to significant levels. Authors of existing models have sought an explanation in the parity-breaking weak nuclear force, in some selectively acting external factor, or in random fluctuations that subsequently became amplified by an autocatalytic process. We have obtained crystals in which l- and d-enantiomers of short RNA duplexes assemble in an asymmetric manner. These enantiomers make different lattice contacts and have different exposures to water and metal ions present in the crystal. Apparently, asymmetry between enantiomers can arise upon their mutual interactions and then propagate via crystallization. Asymmetric racemic compounds are worth considering as possible factors in symmetry breaking and enantioenrichment that took place in the early biosphere.

PubMed: 34107036
DOI: 10.1093/nar/gkab480

実験手法

X-RAY DIFFRACTION (2.29 Å)