7A72
Structure of G132S BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam
Summary for 7A72
Entry DOI | 10.2210/pdb7a72/pdb |
Descriptor | Beta-lactamase, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM, GLYCEROL, ... (5 entities in total) |
Functional Keywords | blac, beta-lactamase, mycobacterium tuberculosis, inhibitor, hydrolase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 28930.39 |
Authors | Chikunova, A.,Ahmad, M.U.,Perrakis, A.,Ubbink, M. (deposition date: 2020-08-27, release date: 2021-07-07, Last modification date: 2024-01-31) |
Primary citation | van Alen, I.,Chikunova, A.,Safeer, A.A.,Ahmad, M.U.D.,Perrakis, A.,Ubbink, M. The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam. Biochemistry, 60:2236-2245, 2021 Cited by PubMed: 34250791DOI: 10.1021/acs.biochem.1c00168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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