7A70

HEW lysozyme in complex with Ti(OH)4

Summary for 7A70

• Entry DOI: 10.2210/pdb7a70/pdb
• Related: 2w1x 2w1y
• Descriptor: Lysozyme, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: lysozyme, titanium, hydrolase, biomineralization
• Biological source: Gallus gallus
• Total number of polymer chains: 1
• Total formula weight: 14673.93

Authors

Calderone, V.,Gigli, L.,Ravera, E.,Luchinat, C. (deposition date: 2020-08-27, release date: 2021-01-13, Last modification date: 2024-10-16)

Primary citation

Gigli, L.,Ravera, E.,Calderone, V.,Luchinat, C.
On the Mechanism of Bioinspired Formation of Inorganic Oxides: Structural Evidence of the Electrostatic Nature of the Interaction between a Mononuclear Inorganic Precursor and Lysozyme.
Biomolecules, 11:-, 2020

PubMed Abstract: Nature has evolved several molecular machineries to promote the formation at physiological conditions of inorganic materials, which would otherwise be formed in extreme conditions. The molecular determinants of this process have been established over the last decade, identifying a strong role of electrostatics in the first steps of the precipitation. However, no conclusive, structure-based evidence has been provided so far. In this manuscript, we test the binding of lysozyme with silica and titania potential precursors. In contrast with the absence of structural information about the interaction with the silica precursor, we observe the interaction with a mononuclear titanium(IV) species, which is found to occur in a region rich of positive charges.

PubMed: 33396930
DOI: 10.3390/biom11010043

Experimental method

X-RAY DIFFRACTION (1.8 Å)