7A6J

Crystal Structure of EGFR-T790M/V948R in Complex with Poziotinib

7A6J の概要

• エントリーDOI: 10.2210/pdb7a6j/pdb
• 分子名称: Epidermal growth factor receptor, 1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: egfr, t790m/v948r, exon20, covalent, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77547.06

構造登録者

Niggenaber, J.,Mueller, M.P.,Rauh, D. (登録日: 2020-08-25, 公開日: 2022-02-23, 最終更新日: 2024-01-31)

• 主引用文献: Lategahn, J.,Tumbrink, H.L.,Schultz-Fademrecht, C.,Heimsoeth, A.,Werr, L.,Niggenaber, J.,Keul, M.,Parmaksiz, F.,Baumann, M.,Menninger, S.,Zent, E.,Landel, I.,Weisner, J.,Jeyakumar, K.,Heyden, L.,Russ, N.,Muller, F.,Lorenz, C.,Bragelmann, J.,Spille, I.,Grabe, T.,Muller, M.P.,Heuckmann, J.M.,Klebl, B.M.,Nussbaumer, P.,Sos, M.L.,Rauh, D.; Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.; J.Med.Chem., 65:6643-6655, 2022; PubMed: 35486541; DOI: 10.1021/acs.jmedchem.1c02080

実験手法

X-RAY DIFFRACTION (2 Å)