7A65
Nanodisc reconstituted, drug-free human ABCB1 in complex with MRK16 Fab
Summary for 7A65
Entry DOI | 10.2210/pdb7a65/pdb |
EMDB information | 11666 |
Descriptor | Multidrug resistance protein 1, MRK16 Fab-fragment light chain, MRK16 Fab-fragment heavy chain, ... (4 entities in total) |
Functional Keywords | p-glycoprotein, mdr1, nanodisc, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 191503.70 |
Authors | Nosol, K.,Locher, K.P. (deposition date: 2020-08-25, release date: 2020-10-14, Last modification date: 2020-10-28) |
Primary citation | Nosol, K.,Romane, K.,Irobalieva, R.N.,Alam, A.,Kowal, J.,Fujita, N.,Locher, K.P. Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proc.Natl.Acad.Sci.USA, 117:26245-26253, 2020 Cited by PubMed: 33020312DOI: 10.1073/pnas.2010264117 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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