7A60

Crystal structure of VIM-2 with hydrolyzed faropenem (ring-open form)

Summary for 7A60

• Entry DOI: 10.2210/pdb7a60/pdb
• Descriptor: Beta-lactamase VIM-2, FORMIC ACID, ZINC ION, ... (5 entities in total)
• Functional Keywords: metallo-beta-lactamase, antibiotic, faropenem, catalysis, antimicrobial protein
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 52570.19

Authors

Hinchliffe, P.,Spencer, J. (deposition date: 2020-08-24, release date: 2021-02-24, Last modification date: 2024-01-31)

• Primary citation: Lucic, A.,Hinchliffe, P.,Malla, T.R.,Tooke, C.L.,Brem, J.,Calvopina, K.,Lohans, C.T.,Rabe, P.,McDonough, M.A.,Armistead, T.,Orville, A.M.,Spencer, J.,Schofield, C.J.; Faropenem reacts with serine and metallo-beta-lactamases to give multiple products.; Eur.J.Med.Chem., 215:113257-113257, 2021; PubMed: 33618159; DOI: 10.1016/j.ejmech.2021.113257

Experimental method

X-RAY DIFFRACTION (1.47 Å)