7A60
Crystal structure of VIM-2 with hydrolyzed faropenem (ring-open form)
Summary for 7A60
Entry DOI | 10.2210/pdb7a60/pdb |
Descriptor | Beta-lactamase VIM-2, FORMIC ACID, ZINC ION, ... (5 entities in total) |
Functional Keywords | metallo-beta-lactamase, antibiotic, faropenem, catalysis, antimicrobial protein |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 52570.19 |
Authors | Hinchliffe, P.,Spencer, J. (deposition date: 2020-08-24, release date: 2021-02-24, Last modification date: 2024-01-31) |
Primary citation | Lucic, A.,Hinchliffe, P.,Malla, T.R.,Tooke, C.L.,Brem, J.,Calvopina, K.,Lohans, C.T.,Rabe, P.,McDonough, M.A.,Armistead, T.,Orville, A.M.,Spencer, J.,Schofield, C.J. Faropenem reacts with serine and metallo-beta-lactamases to give multiple products. Eur.J.Med.Chem., 215:113257-113257, 2021 Cited by PubMed: 33618159DOI: 10.1016/j.ejmech.2021.113257 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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