7A5M

ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-17]-OMe

Summary for 7A5M

• Entry DOI: 10.2210/pdb7a5m/pdb
• Descriptor: Protein enabled homolog, Ac-[2-Cl-F]-[ProM-2]-[ProM-17]-OMe, NITRATE ION, ... (4 entities in total)
• Functional Keywords: proline-rich motif, ena/vasp inhibitor, actin, protein-protein interaction, cell invasion
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 14102.82

Authors

Barone, M.,Roske, Y. (deposition date: 2020-08-21, release date: 2020-10-07, Last modification date: 2024-01-31)

• Primary citation: Barone, M.,Muller, M.,Chiha, S.,Ren, J.,Albat, D.,Soicke, A.,Dohmen, S.,Klein, M.,Bruns, J.,van Dinther, M.,Opitz, R.,Lindemann, P.,Beerbaum, M.,Motzny, K.,Roske, Y.,Schmieder, P.,Volkmer, R.,Nazare, M.,Heinemann, U.,Oschkinat, H.,Ten Dijke, P.,Schmalz, H.G.,Kuhne, R.; Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.; Proc.Natl.Acad.Sci.USA, 117:29684-29690, 2020; PubMed: 33184177; DOI: 10.1073/pnas.2007213117

Experimental method

X-RAY DIFFRACTION (0.78 Å)