7A29

Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) 2-up conformation

7A29 の概要

• エントリーDOI: 10.2210/pdb7a29/pdb
• EMDBエントリー: 11617
• 分子名称: Spike glycoprotein, Neutralising sybody (Sb23), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, complex, nanobody, spike, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 478146.38

構造登録者

Hallberg, B.M.,Das, H. (登録日: 2020-08-16, 公開日: 2020-10-21, 最終更新日: 2020-11-18)

• 主引用文献: Custodio, T.F.,Das, H.,Sheward, D.J.,Hanke, L.,Pazicky, S.,Pieprzyk, J.,Sorgenfrei, M.,Schroer, M.A.,Gruzinov, A.Y.,Jeffries, C.M.,Graewert, M.A.,Svergun, D.I.,Dobrev, N.,Remans, K.,Seeger, M.A.,McInerney, G.M.,Murrell, B.,Hallberg, B.M.,Low, C.; Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.; Nat Commun, 11:5588-5588, 2020; PubMed: 33149112; DOI: 10.1038/s41467-020-19204-y

実験手法

ELECTRON MICROSCOPY (2.94 Å)