7A25

Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23)

Summary for 7A25

• Entry DOI: 10.2210/pdb7a25/pdb
• EMDB information: 11616
• Descriptor: Spike glycoprotein, Sybody 23, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: sars-cov-2, complex, nanobody, spike, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 6
• Total formula weight: 431465.25

Authors

Hallberg, B.M.,Das, H. (deposition date: 2020-08-16, release date: 2020-11-25)

• Primary citation: Custodio, T.F.,Das, H.,Sheward, D.J.,Hanke, L.,Pazicky, S.,Pieprzyk, J.,Sorgenfrei, M.,Schroer, M.A.,Gruzinov, A.Y.,Jeffries, C.M.,Graewert, M.A.,Svergun, D.I.,Dobrev, N.,Remans, K.,Seeger, M.A.,McInerney, G.M.,Murrell, B.,Hallberg, B.M.,Low, C.; Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.; Nat Commun, 11:5588-5588, 2020; PubMed: 33149112; DOI: 10.1038/s41467-020-19204-y

Experimental method

ELECTRON MICROSCOPY (3.06 Å)