7A1F

Crystal structure of human 5' exonuclease Appollo in complex with 5'dAMP

Summary for 7A1F

• Entry DOI: 10.2210/pdb7a1f/pdb
• Descriptor: 5' exonuclease Apollo, FE (III) ION, NICKEL (II) ION, ... (5 entities in total)
• Functional Keywords: dclre1b, snm1b, exonuclease, apollo, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 78868.83

Authors

Newman, J.A.,Baddock, H.T.,Mukhopadhyay, S.M.M.,Burgess-Brown, N.A.,von Delft, F.,Arrowshmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-08-12, release date: 2021-01-20, Last modification date: 2024-01-31)

• Primary citation: Baddock, H.T.,Newman, J.A.,Yosaatmadja, Y.,Bielinski, M.,Schofield, C.J.,Gileadi, O.,McHugh, P.J.; A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.; Nucleic Acids Res., 49:9294-9309, 2021; PubMed: 34387694; DOI: 10.1093/nar/gkab692

Experimental method

X-RAY DIFFRACTION (1.8 Å)