7A1F

Crystal structure of human 5' exonuclease Appollo in complex with 5'dAMP

7A1F の概要

• エントリーDOI: 10.2210/pdb7a1f/pdb
• 分子名称: 5' exonuclease Apollo, FE (III) ION, NICKEL (II) ION, ... (5 entities in total)
• 機能のキーワード: dclre1b, snm1b, exonuclease, apollo, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78868.83

構造登録者

Newman, J.A.,Baddock, H.T.,Mukhopadhyay, S.M.M.,Burgess-Brown, N.A.,von Delft, F.,Arrowshmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (登録日: 2020-08-12, 公開日: 2021-01-20, 最終更新日: 2024-01-31)

• 主引用文献: Baddock, H.T.,Newman, J.A.,Yosaatmadja, Y.,Bielinski, M.,Schofield, C.J.,Gileadi, O.,McHugh, P.J.; A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.; Nucleic Acids Res., 49:9294-9309, 2021; PubMed: 34387694; DOI: 10.1093/nar/gkab692

実験手法

X-RAY DIFFRACTION (1.8 Å)