7A0N
Structure of TSC1 NTD and linker domain
Summary for 7A0N
Entry DOI | 10.2210/pdb7a0n/pdb |
Descriptor | Uncharacterized protein,Uncharacterized protein (1 entity in total) |
Functional Keywords | tsc1, gap, gtpase, signaling protein |
Biological source | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) More |
Total number of polymer chains | 4 |
Total formula weight | 217811.53 |
Authors | Fitzian, K.,Kuemmel, D. (deposition date: 2020-08-10, release date: 2021-05-26, Last modification date: 2024-01-31) |
Primary citation | Fitzian, K.,Bruckner, A.,Brohee, L.,Zech, R.,Antoni, C.,Kiontke, S.,Gasper, R.,Linard Matos, A.L.,Beel, S.,Wilhelm, S.,Gerke, V.,Ungermann, C.,Nellist, M.,Raunser, S.,Demetriades, C.,Oeckinghaus, A.,Kummel, D. TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol.Cell, 81:2705-, 2021 Cited by PubMed: 33974911DOI: 10.1016/j.molcel.2021.04.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.3 Å) |
Structure validation
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