7A0L

Joint neutron/X-ray room temperature structure of perdeuterated Aspergillus flavus urate oxidase in complex with the 8-azaxanthine inhibitor and catalytic water bound in the peroxo hole

7A0L の概要

• エントリーDOI: 10.2210/pdb7a0l/pdb
• 分子名称: Uricase, 8-AZAXANTHINE, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: cofactor-free oxidase, inhibitor, catalytic water, dioxygen binding, oxidoreductase
• 由来する生物種: Aspergillus flavus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34464.83

構造登録者

McGregor, L.,Bui, S.,Blakeley, M.P.,Steiner, R.A. (登録日: 2020-08-09, 公開日: 2020-12-09, 最終更新日: 2024-05-01)

• 主引用文献: McGregor, L.,Foldes, T.,Bui, S.,Moulin, M.,Coquelle, N.,Blakeley, M.P.,Rosta, E.,Steiner, R.A.; Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis.; Iucrj, 8:46-59, 2021; PubMed: 33520242; DOI: 10.1107/S2052252520013615

実験手法

NEUTRON DIFFRACTION (2.1 Å)
X-RAY DIFFRACTION (1.33 Å)